Prof Michael Cheeseman

 

Michael.Cheeseman@roslin.ed.ac.uk

 

Current Research

My primary research interest is the pathogenesis of inflammatory disease of the external ear canal and middle ear using animal models and molecular pathology approaches. The predisposition to ear disease can have a genetic and developmental basis such as the growth retardation of protective nasopharyngeal glands and modified sebaceous glands in the ear canal of EDAR signalling mutant rodent models of hypohidrotic ectodermal dysplasia. The goal is to use comparative pathology of the mouse, rat and dog to shed light on the mechanisms of ear disease in humans.

Collaborators

Dr Denis Headon, University of Edinburgh

Dr Pascal Schneider, University of Lausanne, Switzerland

Dr Jorge del Pozo, University of Edinburgh

Prof Elspeth Milne, University of Edinburgh

Dr Mahmood Bhutta, Brighton & Sussex University Hospitals NHS Trust

Web Links

Selected Publications

A Azar, MF Bhutta, J Del-Pozo, E Milne, M Cheeseman, "Trans-cortical vessels in the mouse temporal bulla bone are a means to recruit myeloid cells in chronic otitis media and limit peripheral leukogram changes". Front. Genet., 28 September 2022, Sec. Genetics of Common and Rare Diseases, Volume 13 - 2022, https://doi.org/10.3389/fgene.2022.985214

J Del-Pozo, DJ Headon, JD Glover, A Azar, S Schuepbach-Mallepell, MF Bhutta, J Riddell, S Maxwell, E Milne, P Schneider,  M Cheeseman The EDA-deficient mouse has Zymbal's gland hypoplasia and acute otitis externa. Dis Model Mech. 2022 Mar 1;15(3):dmm049034. doi: 10.1242/dmm.049034. Epub 2022 Mar 30. PMID: 35107126; PMCID: PMC8990926.

J Li, JD Glover, H Zhang, M Peng, J Tan, CB Mallick, D Hou, Y Yang, S Wu, Y Liu, Q Peng, SC Zheng, EI Crosse, A Medvinsky, RA Anderson RA, H Brown, Z Yuan,  S Zhou, Y Xu, JP KempP, YYW Ho, DZ Loesch, L Wang, Y Li, S Tang, X Wu, RG Walters, K Lin, R Meng, J Lv, JM Chernus, K Neiswanger, E Feingold, DM Evans,  SE Medland, NG Martin, SM Weinberg, ML Marazita, G Chen, Z Chen, Y Zhou, M Cheeseman, L Wang, L Jin, DJ Headon, S Wang. "Limb development genes underlie variation in human fingerprint patterns", Cell. 2022 Jan 6;185(1):95-112.e18. doi: 10.1016/j.cell.2021.12.008. PMID: 34995520; PMCID: PMC8740935.

MF Bhutta, J Lambie, L Hobson, D Williams, HE Tyrer, G Nicholson, S Brown, H Brown, C Piccinelli, G Devailly, J Ramsden, MT Cheeseman, "Transcript analysis reveals a hypoxic inflammatory environment in human chronic otitis media with effusion." Front. Genet., 21 February 2020, Sec. Genetics of Common and Rare Diseases, Volume 10 - 2019,  https://doi.org/10.3389/fgene.2019.01327

J Del-Pozo, N MacIntyre, A Azar, D Headon, P Schneider, M Cheeseman, "Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia" Dis Model Mech. 2019 Apr 25;12(4):dmm037804. doi: 10.1242/dmm.037804. PMID: 31028034; PMCID: PMC6505480.

J Del-Pozo, N MacIntyre, A Azar, J Glover, E Milne, M Cheeseman. "Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model", Dis Model Mech. 2019 Mar 21;12(3):dmm038315. doi: 10.1242/dmm.038315. PMID: 30898767; PMCID: PMC6451434.