Professor Tim Kendall

Research

My research interests run from basic mechanisms of liver disease to histopathological contributions to translational and clinical studies.

Key areas include liver fibrogenesis, primary liver cancer, and metabolic dysfunction-associated steatotic liver disease, including the development and application of computational pathology tools.

I advocate for the role of pathology and pathologists in clinical trials.

Collaborators

Dr Luke Boulter, University of Edinburgh

Prof Jonathan Fallowfield, University of Edinburgh

Prof Prakash Ramachandran, University of Edinburgh

Prof Neil Henderson, University of Edinburgh

Prof Stuart Forbes, University of Edinburgh

Prof Anura Rambukkana, University of Edinburgh

Prof Neil Guha, University of Nottingham

Prof Chiara Braconi, University of Glasgow

Prof Guido Carpino, Sapienza University of Rome

Web Links

Selected Publications

Kendall TJ, Jimenez-Ramos M, Turner F, Ramachandran P, Minnier J, McColgan MD, Alam M, Ellis H, Dunbar DR, Kohnen G, Konanahalli P, Oien KA, Bandiera L, Menolascina F, Juncker-Jensen A, Alexander D, Mayor C, Guha IN, and Fallowfield JA, "An integrated gene-to-outcome multimodal database for metabolic dysfunction-associated steatotic liver disease", Nat Med 29, 2939–2953 (2023). https://doi.org/10.1038/s41591-023-02602-2  

Hess S, Kendall TJ, Pena M, Yamane K, Soong D, Adams L, Truman R, and Rambukkana A, "In vivo partial reprogramming by bacteria promotes adult liver organ growth without fibrosis and tumorigenesis", Cell Reports Medicine 3, 100820 November 15, 2022, https://doi.org/10.1016/j.xcrm.2022.100820

Kendall TJ, Robinson M, Brierley DJ, Lim SJ, O'Connor DJ, Shaaban AM, Lewis I, Chan A and Harrison DJ, "Guidelines for cellular and molecular pathology content in clinical trial protocols: the SPIRIT-Path extension",  The Lancet Oncology, Volume 22, Issue 10, 2021, Pages e435-e445, ISSN 1470-2045, https://doi.org/10.1016/S1470-2045(21)00344-2

Astbury S, Grove JI, Dorward DA, Guha IN, Fallowfield JA and Kendall TJ, "Reliable computational quantification of liver fibrosis is compromised by inherent staining variation", J Pathol Clin Res, 7: 471-481. https://doi.org/10.1002/cjp2.227

Kendall TJ, Duff CM, Thomson AM and Iredale JP, "Integration of geoscience frameworks into digital pathology analysis permits quantification of microarchitectural relationships in histological landscapes", Scientific Reports 10, Article number: 17572 (2020), https://doi.org/10.1038/s41598-020-74691-9

Kendall TJ, Duff CM, Boulter L, Wilson DH, Freyer E, Aitken S, Forbes SJ, Iredale JP and Hastie ND, "Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1", Nature Communications 10, 4688 (2019),  https://doi.org/10.1038/s41467-019-12701-9