Dr David Dorward

Current Research

My main interest is in pulmonary pathology, the role of tissue-derived damage associated molecular patterns and their interaction with cognate receptors on cells of the innate immune system.  In particular, the role of DAMPs in influencing the tumour microenvironment.  Current work is focussed on the G protein coupled receptor formyl peptide receptor 1 which is central in driving neutrophil migration to sites of inflammation while a role in influencing epithelial and tumour cell function is also emerging

Collaborators

Dr Chris Lucas (University of Edinburgh)

Prof Adriano Rossi (University of Edinburgh)

Dr David Moore (University College London)

Dr John Le Quesne (University of Leicester)

Web Links

Full publication list

Selected Publications

Boyapati RK, Dorward DA, Tamborska A, Kalla R, Ventham NT, Doherty MK, Whitfield PD, Gray M, Loane J, Rossi AG, Satsangi J, Ho GT. Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD. Inflamm Bowel Dis. 2018 May 1. doi: 10.1093/ibd/izy095. [Epub ahead of print] PMID: 29718255

Felton JM, Lucas CD, Dorward DA, Duffin R, Kipari T, Vermeren S, Robb CT, MacLeod KG, Serrels B, Schwarze J, Haslett C, Dransfield I, Rossi AG. Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation. J Allergy Clin Immunol. 2018 Feb 8. pii: S0091-6749(18)30215-X. doi: 10.1016/j.jaci.2018.01.029. [Epub ahead of print] PMID: 29428392

Dorward DA, Lucas CD, Doherty MK, Chapman GB, Scholefield EJ, Conway Morris A, Felton JM, Kipari T, Humphries DC, Robb CT, Simpson AJ, Whitfield PD, Haslett C, Dhaliwal K, Rossi AG. Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome. Thorax. 2017 Oct;72(10):928-936. doi: 10.1136/thoraxjnl-2017-210030. Epub 2017 May 3. PMID: 28469031

Dorward DA, Felton JM, Robb CT, Craven T, Kipari T, Walsh TS, Haslett C, Kefala K, Rossi AG, Lucas CD. The cyclin-dependent kinase inhibitor AT7519 accelerates neutrophil apoptosis in sepsis-related acute respiratory distress syndrome. Thorax. 2017 Feb;72(2):182-185. doi: 10.1136/thoraxjnl-2016-209229. Epub 2016 Oct 24. PMID: 27965411

Dorward DA, Lucas CD, Chapman GB, Haslett C, Dhaliwal K, Rossi AG.  The role of formylated peptides and formyl peptide receptor 1 in governing neutrophil function during acute inflammation. Am J Pathol. 2015 May;185 (5):1172-84. doi: 10.1016/j.ajpath.2015.01.020. Epub 2015 Mar 17. Review. PMID: 25791526