Professor of Gynaecological Pathology alistair.r.w.williams@ed.ac.uk The University of EdinburghQueen's Medical Research InstituteEdinburgh BioQuarter47 Little France CrescentEdinburgh EH16 4TJ Current ResearchMy research efforts have long been focused on reproductive pathophysiology, and I have published on a range of topics related to reproductive function, mostly in contraception, management of uterine fibroids, and other benign and malignant gynaecological diseases. My major focus is now on the effects of selective progesterone receptor modulators (SPRMs) on endometrium. I am a member of a very productive clinical and basic science research team led by my colleague Professor Hilary Critchley, conducting research into various aspects of endometrial pathophysiology and mechanisms of abnormal uterine bleeding. I have long experience of participation as a pathologist in a range of clinical trials, and I am involved in pathological assessments of endometrial biopsies in Phase III studies of several SPRMs sponsored by Bayer, Gedeon Richter and Preglem.CollaboratorsProf Hilary Critchley, University of EdinburghProf G Mutter, BostonDr C Bergeron, ParisWeb LinksFull Publication ListSelected PublicationsWhitaker LHR, Williams ARW, Critchley HOD. Selective progesterone receptor modulators. Curr Opin Obstet Gynecol. 2014 Aug; 26(4):237-42. PMID: 24950125Williams, A.R.W., Bergeron, C., Barlow, D.H., Ferenczy, A., 2012. Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate. Int J Gynecol Pathol. 2012 Nov;31(6):556-69. PMID: 23018219Mutter, GL, Bergeron, C, Deligdisch, L, Ferenczy, A, Glant, M, Merino, M, Williams, ARW, Blithe, D (2008). The spectrum of endometrial pathology induced by progesterone receptor modulators. Mod Pathol. 2008 May; 21(5):591-8. PMID: 18246050Kannan, A., Bhurke, A., Sitruk-Ware, R., Lalitkumar, P.G., Gemzell-Danielsson, K., Williams, A.R.W., Taylor, R.N., Bagchi, M.K., Bagchi, I.C., 2017. Characterization of Molecular Changes in Endometrium Associated With Chronic Use of Progesterone Receptor Modulators: Ulipristal Acetate Versus Mifepristone. Reprod Sci 1933719117746764. https://doi.org/10.1177/1933719117746764Sanderson, P.A., Critchley, H.O.D., Williams, A.R.W., Arends, M.J., Saunders, P.T.K., 2016. New concepts for an old problem: the diagnosis of endometrial hyperplasia. Human Reproduction Update. doi:10.1093/humupd/dmw042Williams ARW. Uterine fibroids – what’s new? [version 1; referees: 3 approved]. F1000Research 2017, 6(F1000 Faculty Rev):2109 (doi: 10.12688/f1000research.12172.1)Dinh, A., Sriprasert, I., Williams, A.R., Archer, D.F., A Review of the Endometrial Histologic Effects of Progestins and Progesterone Receptor Modulators in Reproductive Age Women. Contraception. doi:10.1016/j.Contraception.2015.01.008 This article was published on 2024-08-27
